Modern neuroscience demands approaches that allow observing and manipulating activity across the brain, so that we may study not just the role of one small brain region in behavior, but rather study the neural basis of behavior across all the circuits that collectively give rise to it.

To achieve this, we employ a combination of large-scale electrophysiology with novel, ground-breaking Neuropixels probes; widefield calcium imaging; and systematic optogenetics. We employ these methods in combination with a sophisticated behavioral task for mice, which allows the precise quantification of perceptual decision processes, an essential requirement for understanding the link between neuronal activity and behavior.